Publications 2025 – 2021
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2026
1. W.A. Alves, J.E.U. Rojas, A.C.H. Castro, L.T. Kochi, A.C.D.L.V. Reis, F.A.N. Esteves, P.S. Ferreira, F.L. Castro, R.C. Otoni, J.B. Barreto, V.L. Oliveira, A.A. Zaneli. Polymeric Microneedles for Biomedical Applications: Innovations in Transdermal Drug Delivery and Biosensing Technologies. Biomed. Mater. Devices 2025, doi: 10.1007/s44174-025-00330-4.
2. Alves, W.A. Polymeric Microneedles as Analytical Interfaces for Biosensing and Controlled Drug Release: Achievements and Future Challenges. Brazilian Journal of Analytical Chemistry – BrJAC 2026, 13, 13-15.
3. Castro, F.L.; Castro, A.C.H.; Silva, M.R.A.; Ferreira, P.S.; Santos, S.F.; Andrade, L.M.; Venanzi, M.; Cavalieri, F.; Silva, M.O.; Daher, I.P.; Ibrahim, C.H.O.; Oliveira, V.L. ; Kalil, J.; Silva, Tamires L.; Boscardin, S.B.; Alves, W.A. Electrochemical Detection of SARS-CoV-2 in Saliva Using ZnO Nanorods Functionalized with Gold-Conjugated Anti-RBD Antibodies. ChemNanoMat 2026, 12, e202500411.
4. Silva, M.R.A.; Gerbelli, B.B.; Castro, A.C.H.; Aguilar, A.M.; Alves, W.A. Green Peptide-Assisted Synthesis of Gold Nanoparticles for Electrochemical Biosensing of Carbamate Pesticides. Bioinorganics and Biocatalysis 2026, 1, 4. https://www.sciltp.com/journals/bb/articles/2601002769
5. Azevedo, F.V.P.V.; Ruiz, A.L.T.G.; Rodrigues, D.S.; Nakahata, D.H.; Paiva, R.E.F.; Araujo, D.R.; Via, A.C.L.; Alves, W.A.; Requena, M.B.; Kurachi, C.; Stringasci, M.D.; Vollet-filho, J.D.; Lustri, W.R.; Bagnato, V.S.; Abbehausen, C.; Corbi, P.P.; Lima, C.S.P. Navigating the Challenges of Metallopharmaceutical Agents: Strategies and Predictive Modeling for Skin Cancer Therapy. Pharmaceutics 2026, 18, 145.
6. Reis, A.C.L.V.; Castro, A.C.H.; Rojas, J.E.U.; Chiaro, D.A.; Guha, S.; King, G.M.; Oliveira, V.L.; Araujo, D.R.; Tofoli, G.R.; Romero, M.; Mombru, D.; Alves, W.A. Polypyrrole-Coated Microneedle Platform for Offline Electrochemical Detection of Interferon-Alpha in Interstitial Fluid. ACS Appl. Bio Mater. 2026, 9, 2419-2433.
7. Kotelnikov, I.; Mondo, G.B.; Ribeiro, C.A.S.; Sosa, M.M.R.; Alves, W.A.; Batista, B.L.; Pop-georgievski, O.; Proks, V.; Giacomelli, C.; Giacomelli, F.C. Building a Simple Platform for Tailoring Peptide Surface Chemistry to Enhance Cellular Uptake of Polymer-Coated Gold Nanoparticles. ACS Omega 2025, 11, 14626-14637.
8. Araujo, D.R.; Alves, W.A.; Andrade-Oliveira, V. [Editorial] Therapies Applied to Biological Barriers: From Overcoming to Tissue Regeneration. Curr. Top. Med. Chem. 2026, 26, 1-2.
2025
1. B.B. Gerbelli, P.T. Sodre, P.L.O. Filho, M.D. Coutinho-Neto, I.W. Hamley, J. Seitsonen, W.A. Alves. Enhancing Pesticide Detection: The Role of Serine in Lipopeptide Nanostructures and Their Self-assembly Dynamics. J. Colloid Interface Sci. 2025, 690, 137271.
2. F.A. Nunez, M.R.A. Silva, E.M. Cilli, S.T.R. Brandão, M. Müller, D. Fischer, Q.A. Besford, W.A. Alves. Development of Ni-ZnO-ACE-2 Peptide Hybrids as Electrochemical Devices for SARS-CoV-2 Spike Protein Detection. Bioelectrochemistry 2025, 163, 108899.
3. S.V. Vassiliades, K.A.B. Argüello, C.E. Castro, C.A. Silva, A.C. Gonzalez, P. Homem-de-Mello, I.L. Nantes, A.M. Aguilar, G. Barbosa-Reis, D. Oliveira-Silva, F. Giuntini, W.A. Alves. Synthesis, Photophysical Properties, and Photocytotoxic Effects of Porphyrin-Diphenylalanine Conjugates on HeLa Cells. J. Mol. Struct. 2025, 1322, 140545.
4. L.R.F. Barros, C.E. Castro, A.P. Rosso, R.C. Duarte, A.G. Dal-bó, W.A. Alves, F.C. Giacomelli. Sugar-Decorated Cholesterol-Core Nanoparticles as Potential Targeting Nanomedicines for the Delivery of Lipophilic Drugs. RSC Pharmaceutics 2025, 2, 387-397.
5. J.E.U. Rojas, L.M. Andrade, F. Giuntini, W.A. Alves. Development and Characterization of Silk Fibroin-Enriched 3D Printed Hydrogels for Photosensitizer Delivery. Materialia 2025, 40, 102402.
6. E.R. Nascimento, M.L. Souza, A.G. Brolo, W.A. Alves. Spectroelectrochemical Analysis of Oxygen Evolution by Nickel Hydroxide: Role of Oxygen Vacancies, Charge Transfer, and Silk Fibroin. Adv. Mater. Interfaces 2025, 12, 2500190
7. P.S. Ferreira, B.B. Gerbelli, J. Cantero, F. Iribarne, A.C.H. Castro, L.T. Kochi, F.L. Castro, W.A. Alves. Influence of Cholesterol on the Insertion and Interaction of SARS-CoV-2 Proteins with Lipid Membranes. ACS Appl. Bio Mater. 2025, 8, 5380-5394.
8. F.A. Nunez, V.L. Oliveira, C. Remuzgo, M.R. Araujo-Silva, I. Daher, J.R. Oliveira, T.L. Silva, E. Cunha-Neto, J. Kalil, K.S. Santos, Q.A. Besford, W.A. Alves. Electrochemical Immunosensor for Antibody Recognition Against SARS-CoV-2 B-Cell Epitope: Impact of RBD Mutations on Antigen-Antibody Binding. J. Mater. Chem. B 2025, 13, 9925-9936.
9. A.E. Sabaine, A.C.H. Castro, R.S.N. Mancini, M.R. Araujo-silva, A.F. Sepulveda, J.R. Oliveira, C. Remuzgo, K.S. Santos, V.L. Oliveira, L.T. Kochi, L.T. Kubota, M.B. Mamian-lopez, W.A. Alves. Peptide-Based Biosensors for Variant-Specific Detection of SARS-CoV-2 Antibodies. Mater. Adv. 2025, 6, 7090-7103.
10. Piraja, J.; Teixeira, A.R.F.; Factori, I.M.; Sepulveda, A.F.; Setz, L.F.G.; Ribeiro, A.O.; Alves, W.A. Electrospun Polyamide 6 Nanofibers As Controlled Delivery System For Enhanced Photodynamic Therapy. Quim. Nova 2025, 48, e-20250238.
11. Sepulveda, A.F.; Oliveira, L.F.; Pelosine, A.M.; Alves, W.A.; Araujo, D.R. Tuning Pluronic Hydrogel Properties via Ionic Strength and Hyaluronic Acid for Optimized Rheology and Drug Delivery Performances. ACS Omega 2025, 10, 60519-60531.
2024
1. P.S. Ferreira, B.B. Gerbelli, A.C.H. Castro, B. Cortez, F.L. Castro, J. Cantero, F. Iribarne, I.W. Hamley,
W.A. Alves. Exploring the Use of a Lipopeptide in Dipalmitoylphosphatidylcholine Monolayers for Enhanced Detection of Glyphosate in Aqueous Environments. Langmuir 2024, 40, 13583-13595.
2. P.T. Sodre, A.M. Aguilar, W.A. Alves, M.D. Coutinho-neto. Intrinsic and Environmental Modulation of Stereoselective Aldol Organocatalyzed Reactions by Proline-Containing Lipopeptides. RSC Adv. 2024, 14, 21035-21046.
3. J.N.Y. Costa, G.J.C. Pimentel, J.A. Poker, L. Merces, W.J. Paschoalino, L.C.S. Vieira, A.C.H. Castro, W.A. Alves, L.B. Ayres, L.T. Kubota, M. Santhiago, C.D. Garcia, M.H.O. Piazzetta, A.L. Gobbi, F.M. Shimizu, R.S. Lima. Single-Response Duplexing of Electrochemical Label-Free Biosensor from the Same Tag. Adv. Healthcare Mater. 2024, 1, 2303509.
4. I.M. Factori, E.R. da Silva, B.B. Gerbelli, M.S. Liberato, D.R. de Araujo, W.A. Alves. PVA/titanate nanotube nanocomposites: Evaluating the required structural properties for their performance as macromolecule delivery systems. J. Appl. Polym. Sci. 2024, e56226.
2023
1. F.A. Nunez, A.C.H. Castro, V.L. Oliveira, A.C. Lima, J.R. Oliveira, G.X. Medeiros, G.L. Sasahara, K.S. Santos, A.J.C. Lanfredi, W.A. Alves. Electrochemical Immunosensors Based on Zinc Oxide Nanorods for Detection of Antibodies Against SARS-CoV-2 Spike Protein in Convalescent and Vaccinated Individuals. ACS Biomater. Sci. Eng. 2023, 9, 458-473.
2. F.A.N. Esteves, A.C.H. Castro, I.P. Daher, E. Cunha-neto, J. Kalil, S.B. Boscardin, A.J.C. Lanfredi, V.L. Oliveira, W.A. Alves. ZnO-Based Electrochemical Immunosensor to Assess Vaccine-Induced Antibody-Mediated Immunity against Wild-Type and Gamma SARS-CoV-2 Strains. Biosensors 2023, 13, 371.
3. W.Y. Oyadomari, G.L. Anthero, M.R.A. Silva, L.C. Porta, V. Oliveira, P.F. Reid, O.A. Sant’anna, J.V. Nani, W.A. Alves, M.A.F. Hayashi. Evaluation of Tumor Growth Remission in a Murine Model for Subcutaneous Solid Tumors – Benefits of Associating the Antitumor Agent Crotamine with Mesoporous Nanosilica Particles to Achieve Improved Dosing Frequency and Efficacy. Int. J. Pharm. 2023, 646, 123420.
2022
1. W.A. Alves, G. King, S. Guha. Looking into a crystal ball: printing and patterning self-assembled peptide nanostructures. Nanoscale 2022, 14, 15607-15616.
2. L.R. Mello, V. Carrascosa, E.R.L. Oliveira, M.A. Juliano, I.W. Hamley, V. Castelletto, S.V. Vassiliades, W.A. Alves, C.R. Nakaie, E.R. Silva. Nanostructure Formation and Cell Spheroid Morphogenesis of a Peptide Supramolecular Hydrogel. Langmuir 2022, 38, 3434-3445.
3. A.C.H. Castro, I.R.S. Bezerra, A.M. Pascon, G.H. da Silva, E.A. Philot, V.L. de Oliveira, R.S.N. Mancini, G.R. Schleder, C.E. Castro, L.R.S. de Carvalho, B.H.V. Fernandes, E.M. Cilli, P.R.S. Sanches, M. Santhiago, I. Charlie-Silva, D.S.T. Martinez, A.L. Scott, W.A. Alves, R.S. Lima. Modular Label-Free Electrochemical Biosensor Loading Nature-Inspired Peptide toward the Widespread Use of COVID-19 Antibody Tests. ACS Nano 2022, 16, 14239-14253.
4. R.S.N. Mancini, A.E. Sabaine, C.E. Castro, J.B.T. Carnielli, R. Dietze, V.L. Oliveira, A.J.C. Lanfredi, L.T. Kubota, M.B. Mamian-Lopez, W.A. Alves. Development and Validation of a SERS-Based Serological Test Combined with PLS-DA Method for Leishmaniasis Detection. ACS Appl. Electron. Mater. 2022, 4, 3997-4006.
5. B.B. Gerbelli, P.L.O. Filho, B. Cortez, P.T. Sodre, M.D. Coutinho-Neto, I.W. Hamley, J. Seitsonen, W.A. Alves. Interaction between glyphosate pesticide and amphiphilic peptides for colorimetric analysis. Nanoscale Adv. 2022, 4, 3592-3599.
6. J.E.U. Rojas, V.L. Oliveira, D.R Araujo, G.R. Tofoli, M.M. Oliveira, D.J. Carastan, M. Palaci, F. Giuntini, W.A. Alves. Silk fibroin/poly(vinyl alcohol) microneedles as carriers for the delivery of singlet oxygen photosensitizers. ACS Biomater. Sci. Eng. 2022, 8, 128-139.
7. E.R. Nascimento, B.B. Gerbelli, F.F. Ferreira, F.N. Costa, P.A. Chater, W.A. Alves. Interfacial Self-Assembly of Silk Fibroin Polypeptides and α-NiCo(OH)2 Nanocrystals with Tunable Energy Storage Applications. ACS Appl. Electron. Mater. 2022, 4, 1214-1224.
8. C.Y.N. Nicoliche, A.M. Pascon, I.R.S. Bezerra, A.C.H. de Castro, G.R. Martos, J. Bettini, W.A. Alves, M. Santhiago, R.S. Lima. In Situ Nanocoating on Porous Pyrolyzed Paper Enables Antibiofouling and Sensitive Electrochemical Analyses in Biological Fluids. ACS Appl. Mater. Interfaces 2022, 14, 2522-2533.
2021
1. P. Dognini, C.R. Coxon, W.A. Alves, F. Giuntini. Peptide-Tetrapyrrole Supramolecular Self-Assemblies: State of the Art. Molecules 2021, 26, 693.
2. B.M. Soares, P.T. Sodre, A.M. Aguilar, B.B. Gerbelli, J.N.B.D. Pelin, K.B. Arguello, E.R. Silva, M.A. Farias, R.V.Portugal, C. Schmuck, M.D. Coutinho-Neto, W.A. Alves. Structure Optimization of Lipopeptide Assemblies for Aldol Reactions in an Aqueous Medium. Phys. Chem. Chem. Phys. 2021, 23, 10953-10963
3. P.S. Elenovskii, K. Romanyuk, M.S. Liberato, P. Brandao, F.F. Ferreira, S. Kopyl, L.M. Mafra, W.A. Alves, A.L. Kholkin. 2D Layered Dipeptide Crystals for Piezoelectric Applications. Adv. Funct. Mater. 2021, 2102524. DOI: 10.1002/adfm.202102524
